-it's now or never...if they extend for two full years we know cve is working in their clinics 

Unfortunately, it can't be "working in their clinics" or we would see a trial registered at clinicaltrials.gov. 

- if they decline to continue with us it's all over ..

It wouldn't help us get to a buck anytime soon, but it's certainly not "all over". Chiesi has a decent chance for a clinical trial IMO.  And BTI folks are anticipating additional partnerships this year.