Re: The Insulin Pill Gets Real? A Chat with Oramed’s CEO
in response to
by
posted on
Dec 01, 2012 05:24PM
Edit this title from the Fast Facts Section
The molecular wt listed is for the monomer. I'm no expert on insulin, but what I've read is that in solution, insulin tends to form dimers. In the presence of zinc, these dimers form hexamers. In the body, insulin is stored as the hexamer, which is inactive and has long-term stability.
So it's possible these guys can encapsulate a monomeric insulin. But there's a time delay passing through the gut and getting it absorbed into the body.
Somewhere on their website, it says they see the first signs of insulin release at 15 minutes, a max concentration at 1 hour, and a fall-off until 2 hours post administration.