Welcome To The Mannkind HUB On AGORACOM

Edit this title from the Fast Facts Section

Free
Message: Re: The Insulin Pill Gets Real? A Chat with Oramed’s CEO

The molecular wt listed is for the monomer. I'm no expert on insulin, but what I've read is that in solution, insulin tends to form dimers. In the presence of zinc, these dimers form hexamers. In the body, insulin is stored as the hexamer, which is inactive and has long-term stability.

So it's possible these guys can encapsulate a monomeric insulin. But there's a time delay passing through the gut and getting it absorbed into the body.

Somewhere on their website, it says they see the first signs of insulin release at 15 minutes, a max concentration at 1 hour, and a fall-off until 2 hours post administration.


Dec 03, 2012 06:28PM

Dec 03, 2012 08:45PM
1
Dec 04, 2012 01:57AM

opc
Dec 04, 2012 02:21AM

Dec 04, 2012 08:21AM

Dec 04, 2012 10:08PM
Share
New Message
Please login to post a reply