Re: ADA 2012: Early Use of Insulin of No Benefit, Though No Harm:Study
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posted on
Jun 13, 2012 09:19PM
Edit this title from the Fast Facts Section
Here's an approximate timelime for complications that can be expected from poorly controlled diabetes. While cardiovascular complications are very important, it is usually not the first thing I worry about. So I would not expect cardiovascular symptoms early in the disease course. OTOH, early insulin use may have some benefit in preventing some of the other complications - but this article makes no mention as that was not the focus of their study.
http://virtuallabs.stanford.edu/diabetes/Timeline.pdf
These timelines depict the rough progression of complications in poorly controlled type 1 and type 2 diabetes mellitus. Also indicated are the time points at which screening for certain complications is recommended.
Type 1
Diagnosis: Organs highlighted – Kidneys, Pancreas
- Polyuria/polydipsia can signal diabetes onset
- Diabetic ketoacidosis may be the presenting feature of diabetes
5 years: Organs highlighted – Eyes, Nerves, Peripheral Vascular (Arteries), Kidneys
- Microalbuminuria begins
- Annual foot exams, eye (including retinal) exams, and urine screening exams should
begin
10 years: Organs highlighted – Eyes, Kidneys
- 60% of people with poorly controlled diabetes have retinopathy at this point
- Overt nephropathy may be present
15 years: Organs highlighted – Eyes, Cardiovascular
- Blindness resulting from diabetic retinopathy may occur
- Cardiovascular complications become symptomatic
20 years: Organs highlighted - Kidneys
- End-stage renal disease may occur after years of nephropathy
Anytime: Organs highlighted – Pancreas
- Diabetic ketoacidosis may occur, especially with infection or non-compliance with
insulin regimen
Life Expectancy: Organs highlighted – n/a
- Due to the complications of the disorder, life expectancy is 7 to 10 years shorter for
people with poorly controlled diabetes than for people without it.