This is nothing new,we've all heard that you can take Afrezza,eat nothing,and still no hypoglycemia.But it's interesting to see how much it lowered HBA1C.

Abstract

Background: This pilot trial was designed to determine if an optimal dose of Technosphere® insulin (TI) inhalation powder (MannKind Corp., Valencia, CA) could be used regardless of variation in meal carbohydrate (CHO) content.

Subjects and Methods: In total, eight subjects (seven men, one woman) with type 2 diabetes were enrolled. Subjects underwent dose optimization meal challenge (MC) visits (100% CHO) and MCs with varied CHO meal contents (50%, 200%, and 0% calculated CHOs). Primary end point was change in postprandial glucose (PPG) excursions. Baseline demographics were 60±7 years of age, diabetes duration of 12.3±4.27 years, hemoglobin A1c (A1C) of 7.82±1.04%, and body mass index of 31.3±5.48 kg/m2.

Results: Maximum mean PPG excursions for the nominal 100% CHO meals were −13±15 mg/dL for breakfast (B) and −14±15 mg/dL for lunch (L), similar to those after 50% CHO meals (B, −17±16 mg/dL; L, +14±10 mg/dL). The largest excursions occurred during 200% CHO meals and remained below American Diabetes Association targets (B, +19±16 mg/dL; L, +32±29 mg/dL). During 15 of the MCs, subjects took their usual TI dose and then had no meal (0% CHO). For the 0% CHO MCs, the largest mean PPG excursion were −33±9 mg/dL at 60 min (B) and −31±10 mg/dL at 60 and 90 min (L). Mean A1C dropped from 7.82±1.04% at the Week 1 visit to 6.18±0.46% (P=0.00091) at the Week 19 visit.

Conclusions: Results in eight patients suggest that once an optimal dose of TI is determined, type 2 diabetes patients can ingest meals with a wide range of CHO content or even skip meals without severe hypoglycemia. During this pilot study TI therapy improved A1C by −1.63% (P=0.00091) during 19 weeks of treatment.

http://online.liebertpub.com/doi/abs/10.1089/dia.2012.0101