How much risk can you tolerate? You can buy a relatively large number of shares for a little money. If you're willing to take the risk that at least one product will be successful, you stand to do quite well. If you think this company has no chance, then don't buy. Is there some reason for hope? Well, while they haven't succeded yet, they haven't failed either. As long as they keep trying new things, there's reason for hope. Also, the lastest PR on Oraphyte indicated there could be a deal with DuPont by the end of the year. How much patience do you have? Only you can make the final decision.