Koo...a quick thought. My opinions, such as they are, basically amount to ifs predicated on maybes. We'll just have to see how it plays out. If or when RVX makes its orphan indication announcement we'll see where short interest is at that point....If they make an annoucement, and just prior the number of shares shorted drops dramatically, then imo something smells, and it might behoove investors to ask if there is any connection between those engaged in the shorting and company insiders.