Bear, thanks for your comments regarding this paper, very helpful. I think RVX needs to do a lot more for lay investors to separate itself from pan selective BET inhibitors from the safety perspective. Perhaps a blog or two on this subject would be helpful. As to Fuzzyjr's question, yes it is the same Jones trading. As I mentioned in an earlier post I think a lot of their sales were on behalf of Mike Sweeney as his trading volumes matched Jones exactly on some days as per insider trading disclosures. Hard to believe it would be coincidence.