Koo-Koo2 wrote "I don't believe Apabetalone fixes diabetes??? Or does it?"

You are correct. So far there has been very little disclosed/published on the effects of RVX-208/apabetalone on glucose metabolism, pancreatic insulin secretion, or tissue insulin sensitivity.

The one study was the Austrailian study in men with pre-diabetes treated for 31-35 days. However, "there was no change in fasting glucose (placebo: 5.8 ± 0.6 vs RVX-208: 5.9 ± 0.6 mmol/L) or fasting insulin (placebo: 9.3 ± 6.2 vs RVX-208: 9.2 ± 5.2 mU/L) between treatments." Furthermore, both groups behaved very similarly in response to an oral glucose tolerance test (OGTT). Fasting and post-glucose plasma incretin (GIP and GLP-1) concentrations were also similar between groups. They also administered a stable isotope of glucose to allow for some glucose kinetic modeling. They observed some statistically significant, though modest, effects of RVX-208 to: 1) lower the rate of glucose appearance into blood; 2) lower the rate of glucose disappearance from blood (indirect measure of tissue glucose uptake); 3) marginally suppress endogenous glucose production; 4) reduce and delay the appearance of the ingested glucose load; 5) lower glucose clearance when calculated over the entire OGTT.

Overall, these effects were modest and nothing to write home over. Definitely nothing to get excited about in terms of promoting RVX-208 as a diabetes treatment from the perspective of glucose control, insulin secretion or insulin sensitivity. 

"Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial." 

However, we do know that from the post-hoc analysis of SUSTAIN and ASSURE, that patients with diabetes treated with RVX-208 not only showed reduced MACE but "tended to have lower blood glucose vs. placebo. But specifically in patients with DM who had low HDL, the blood glucose was significantly lower following treatment with RVX-208 vs. placebo.  Furthermore, the time required for RVX-208 to reduce blood glucose was not observed until at least 12 weeks following initiation of treatment." That was taken from this July 2014 news release.

BearDownAZ