Bear,

Maybe I am drinking the koolaid but I have to think that the DSMB would not allow a 3 year trial to coninue that long if RVX 208 in the betonmace trial control group has absolutely no effect compartively to the placebo group.  would not be ethical, I could be wrong as I have never had any involvement in any clinical trial and have limited understanding of it

However this was a good find from F6 from  IV

http://www.investorvillage.com/smbd.asp?mb=10603&mn=26451&pt=msg&mid=17134149

Data Monitoring Committees — Expect the Unexpected...and more.

http://www.nejm.org/doi/full/10.1056/NEJMra1510066#t=article

http://www.fda.gov/downloads/regulatoryinformation/guidances/ucm127073.pdf

I am hoping this sheds light that 3 DSMB passes over 18 months shows things are on the right path,  I hope, its nive we see your other views , refreshing