I've seen companies like HMPR do reverse splits and explode higher by 1,000%, EQIX is another....there's no one size fits all answer. 

If a RS is done from a position of strength it can be a positive.....averages are all well and good, but in a lot of cases share consolidations are done to maintain listing compliance on an exchange like the Nasdaq.  

Getting off the pinks imo would be worth it and is a more realistic path than some hypothetical CVR dea.