Hi Bear,

I differently see your viewpoints and that some of my views are conjecture

with your comment below, do you know if any of the other cardivascular outcome trial you mentioned have had any postive results  with 5 point MACE outcome. The Assure trial   had  a 77% RRR in the post hoc analysis   with low hdl patients with Diabetes... so my hope is we can repeat or come close with a 3 point mace outcome.

"  Plenty of recent cardiovascular outcomes trials in diabetes patients have gone to completion and found to have no significant effect to reduce the 3-point MACE primary outcome. In my opinion, a potential interim statistical analysis (i.e. the sample size re-estimation analysis at 75% of planned events = ~188 events"