"But do Epigentics, and/or BET Inhibition in general and Apabetalone in particluar target "Cardiometabolic Risk"?"
The American Diabetes Association definitely thinks that Type 2 Diabetes and Cardiovascular Disease have something to do with cardiometabolic risk. BETonMACE is being tested in high-risk Type 2 Diabetes subjects with cardiovascular disease.
https://professional.diabetes.org/sites/professional.diabetes.org/files/media/cardiometabolicrisk2015.pdf