Thanks BDAZ.

So, here is a very elementary and naive analysis with tons of assumptions.

If the event rate is 7.2% and management says that we have about 10 to 15 events per month or an average of 12.5 events per months, we get a sample size of 2084 approximately.

This is evenly divided between the control group and experimental group or 1042 each, (though i suspect the depletion rate should be more from the control group if the medicine is working).

From a former post by TOPCOIN, 86,788 control arm particpants and they had 7657 3pt MACE or a rate of 8.8%. Can we use this rate for our control group?

If so, then we get a number of 7.641 events per month for the control group. The number for the experimental group should then be 4.863 events per month (assuming an average of 12.5 events per months).

This gives us a RRR of 36%. One major assumption here is that the RRR was similar for the first 200 MACE events.

Does this analysis have any value?????