jupiter - Not being a science guy I can only relate it to something I'm a little familiar with. In golf if you hit the sweat spot the ball goes down the middle. It might not go really far but doesn't get you into trouble either. If your off on your alignment just a little you draw or fade. If your alignment is off to much you hook or slice. To me this whole drug development is similar to finding the sweat spot down the middle over and over again. When I heard that RVX/Zenith had narrowed their field from 300,000 molecules down to 4,000 it seemed to me that the sweat spot was getting closer.

tada