".....the fact that it is taking longer to get to 250 MACE events than estimated back at the AGM....."

Depends on what AGM info you are looking at. Yes, they indicated that they expected end of dosing by end of 2018. Based on that, yes it is taking longer. However, they also based that estimate off of being at ~200 events at the AGM w/ events happening in the range of 10-15 events per month. ~ 4 months past AGM, so projecting off of their numbers gives us a 240-260 expected range. So based on that it is too early to state that it is taking longer than what was stated at the AGM. In answer to your other question, yes I think that the announcement of end of dosing/hitting 250 will get the share price moving. Just my opinion. DYODD.

BDAZ