Hear hear....for me its simply a countdown to 250 events right now, recognizing the human suffering that entails, but also noting bear's astute observation that without that pain the science cannot advance, and the potential for improving life for millions of people goes nowhere.  

The annoying thing is trying to do a countdown without any way to know what point we're at or how fast or slowly we're moving toward it.  Are we down to days, weeks, a couple months?  

I just wonder what it might take to get the damn to finally break.  I still believe that there are big players who want in, either to establish a position or to add to an existing one....big players using short selling as a tool to keep their foot on the PPS and to stop it from taking off.

With biotech it just seems to take one big announcement...and then things can exlode like ESPR and AMRN have.  We have had big moves too, but not with the volume that other stocks have seen.

If I'm right that there are big players wanting to establish or add substantially to their positions....what will it take to get them to take their foot off the brake and simply engage in the kind of buying activity that could vault our PPS to another level?  

Will 250 MACE be enough for it to happen?  Could that be the catalyst that makes waiting no longer worth the risk....250 starts the countdown to top-line with the potential that we might see 30% or more RRR reported?  Or might the foot come down again to hinder any upward movement and to frustrate current shareholders....

Yeah, I'm impatient....but another few months is nothing against the 5 years I've already been waiting.