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Message: Any thoughts to why BETonMACE patient median eGFR is so high?

You're right.

Just did a little more digging, and you can find a break down of LIXA and EXAMINE in their supplementary info.

LIXA - eGFR (mL/min/1.73m2). 

 

 

[15-30] = 0.1%

[30-60] = ~23.5%

[60-90] = ~ 53.4%

  [>90] = ~ 23%  

EXAMINE - eGFR

   [<30] = ~2.9%

[30-60] = ~26.2%

[60-90] = ~37.3%

  [>90] = ~15.6%

 

BETonMACE has a Median of 99. Thus 50% are > 99, which is far healthier than any of those trials. Furthermore, the company has stated that 30 < 11% < 60. Which means 39% are between 99 and 60.

BETonMACE - eGFR

   [<30] = 0%

[30-60] = ~11%

[60-99] = ~39%

  [>99] = ~50%

 

As you can clearly see, BETonMACE patients have much better kidney health than one would expect. Especially at such a late age, having had a Heart Attack, and type two diabetes.

Kidney eGFR does not matter that much for MACE outcomes until you fall below 60 threshold, where it picks up a lot of steam. More information on that in Figure 1a in this link

 

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