"Instead, BET inhibition is more related to turning off, or dimming, overactive genes."

I hit the submit button before I completed my train of thought. Most of the advertised effects of apabetalone deal with decreasing expression of genes. However, apabetalone can also increase the expression of certain genes and the levels of the encoded protein. For example apo-AI is increased by apabetalone. To my knowledge, the mechanism by which apabetalone increases apo-AI has not been revealed. However, it is possible that apabetalone decreases the expression of a negative transcriptional regulator of apo-AI. A double negative. Inhibitting an inhibitor. This exemplified how apabetalone may lead to increased expression of some genes. 

BearDownAZ