iconoclast - I'm inclined to believe the share price will continue to climb the wall of worry going into Top Line. The plus is that the potential pot of gold at the end of this rainbow is to large to not have at least a small position prior to top line. If 25k or 50k investors take that attitude it can create upward pressure. The way to create that awareness is to tell the story to a lot of people. That seems to be what the company is doing and to boot they are using DR Wong a lot more today to tell the story than I ever remember in the past. They should get DR Kolickowski? out to tell the story as well. The challenge is that this is relatively new science  that many have either never heard of or have heard very little of. It could end up being a case of show me first and then I'll play in the sandbox with you.

I'm hopping for 40% or better RRR so that it will be close to impossible for biotech investors to not pay attention. The challenge is that will help after Top Line but not before. 

So I guess that leaves my prediction at; the share price will go up and down prior to the Top Line announcement.

tada