The anti-IL-1β antibody canakinumab in CANTOS was designed to test the inflammation hypothesis in cardiovascular disease but also found benefit in lung cancer. Dr. Paul Ridker, lead CANTOS investigator, discusses "Effect of IL-1β inhibition on lung cancer sheds new light on the role of inflammation."
https://pace-cme.org/2019/05/28/effect-of-il-1-inhibition-on-lung-cancer-sheds-new-light-on-the-role-of-inflammation/
Apabetalone has potent anti-inflammatory effects. What kind of surprises might apabetalone have in store beyond cardiovascular, renal and cognition? Apabetalone as a cancer drug? No proof yet, but BETonMACE full data will be interesting to see!
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