"hey tada. I'm not sure why anyone cares about the RRR, at least up front. As has been pointed out numerous times the key stat is time to first 3 point MACE event."

The two go hand in hand. If the two groups are found to be significantly different in the time to first 3-point MACE, it is the event rates of the two groups at the median dosing (or follow up) period that is used to calculate the %RRR. Furthermore, the greater the relative risk reduction (RRR), the greater the absolute risk reduction (ARR) , and the lower the number needed to treat (NNT) to prevent one event. The greater the RRR and ARR, the lower the NNT, the better. A statistically significant, but modest, effect on RRR/ARR/NNT will not make as big of a splash as a statistically signing and huge RRR/ARR/NNT.

BearDownAZ