Can someone clarify how this idea that Apabetalone along with Crestor worked great but not with Lipitor in Phase 3?  

I know this is what was seen in Phase 2, but I also remember DM saying that that was a spurious correlation.  I don't remember what reason he gave.

If indeed Apabetalone works great with only Crestor but not with Lipitor, then it will be a significant head wind for any price we get.  It is one thing to miss primary end points by "rigorous academic requirements"...it is something else to miss it completely for one statin altogether.  It may turn out to be a deal breaker for the FDA, which will be already questioning why they should approve a drug that missed primary end points.  What mystifies me is where all this talk about Crestor/Lipitor for Phase 3 came from.