Re: Just back from IR,...
in response to
by
posted on
Oct 29, 2019 05:58PM
Toinv - I am no scientist but Rosuvastatin is water soluable and Atorvastatin is lipid soluable (lipophilic). They do have different effects on insulin and diabetes. Below is something I found that maybe our scientists could expand on further as to possible differing interactions.
https://www.gpnotebook.co.uk/simplepage.cfm?ID=x20120104193906598025
"Insulin resistance:
To your functional HDL point, I believe you are referring to Merck's Anaceptrapib. At the same time the ASSURE results were announced, Merck made a big splash with results of a huge increase in HDL. Anaceptrapib is a CETP inhibitor and RVX had already disclaimed these drugs as raising non-functional HDL because when used up, these drugs weren't allowing the HDL to be removed from the body. The HDL volume went way up without improved effectiveness. I believe Merck continued testing and concluded in about 2017 that they were not getting any 3 point MACE improvement from the higher HDL levels but continued trying to develop the drug for LDL lowering. This is from my memory so hopefully not too far off and I am not sure if they are still pursuing this or not.