Brilliant noretreat....I'm reminded of the tale about a bus that got wedged in NYC's Holland tunnel (probably not a true story, but the point is solid).  While engineers and city workers were discussing how to 'unstick' the bus a little girl stuck her head out of the window of a car and said:  "Why not just let the air out of the tires".   Sometimes the simplist approaches are missed by our need to complicate things.

I just sent IR an email, not Don....but we'll see if they answer:

And BDZ thanks for your further answer, pouring even more cold water on my hope for statistical significance on the primary endpoint....I have little doubt you're bang on the money, regardless of how much I'd like you to be wrong :-)

Here's the email I sent to IR.