Very interesting day yesterday. I have now moved from Hail Mary optimistic to super cautiously optimistic. I was moving towards cautiously optimistic until I had my dose of reality. 

I sent the call link to a Big Pharma friend of mine who has been a very practical sounding board over the last couple years and who has constantly politely reminded me that most investors really have no clue what’s going on with the science, since he only partly does and he is in the biz. 

He had counselled me numerous times the initial trial was likely not powered enough and the top line risk was way higher than I kept giving it.  

Anyways, he was far less impressed with the call than me and seemingly all of the board. Now this is not surprising, since I have talked to some high profile cardio guys who have quickly dismissed the trial (does not make them right, but always grounds you). He told me essentially zero chance FDA would ever fast track, the bolt on should be considered a given and the only ground he gave somewhat grudgingly was the Forrest graph – he said that if it is anywhere like the example provided, it would definitely pique the interest of pharma. 

I guess I am officially a half glass empty guy as I have spilled so much of my full glass of wine on my bank book.