jupe, good to see there is a rule of thumb in science. It also a theorem in probability theory (called multiple comparisons) so it's pretty solid.

That being said, as I've posted before, there seems to be promising science in epigenetics and RVX and I think both RVX and ZE are going to need someone to carry them forward in order to move this science toward a business.

I actually believed Don or at least I drew the conclusion from the top line presentation that BoM was a near miss statistically. I was therefore thinking p=0.06 or even 0.07 which already would be a big failure but these results are not even close.

So if Don was that badly mislead by his science people it is time for him to resign and if his science people mislead him down this path it raises serious questions about the management of both of these companies.

It really is not fair for me to try to be a Monday morning quarterback but in hindsight decisions like not doing the futility analysis seem to be mistakes. Not an easy decision because of time and thus money. It is what it is. We must remember that RVX was about to lose it's TSX listing unless it could prove it would remain a going concern. Don has been scrambling for years but he has kept the ship afloat.

Time for RVX to take what it can get and let big money move this forward. It's too important to health not to get this ship sailing again.

All IMHO. Frustrated yet long. Sure want to see Don's song and dance tomorrow. What on earth will he say...hopefully a buyout at a reasonable price?

Also, I do want to thank the science posters, clinicians and others for digging deep to find the positives. From what I have read there is a lot of food for thought on further interesting scientific exploration.

 GLTA

Toinv