After initial elation over the eGFR total population results, it was noted that it went the wrong way. It was then stated that this was statistically significant but not clinically significant and we would have to wait for the CKD sub-study. Could our scientific and statistical experts please comment on the Sub-study Forest Plot for this category. To me it appears that the dot for the higher eGFR group is just to the left (beneficial) side of the ONE line while for the eGFR<60 sub-study population was substantially to the beneficial side.

Any clarification would be appreciated! RVXot