Great question iconoclast; 

Take a look at slide 42 of Don McCaffrey's presentation on Nov 18. 

"Breakthrough Therapy status filings, both FDA and EMA, over the next 90-120 days".  

My question is for what?  It has to be either Renal Disease or Dementia. 

My bet is that it has something to do with <60 eGFR, apabetalone, SGLT2 and Crestor.

tada