Thanks for that,... i didn't know there were alot of other companies digging in the same sandbox:

iBETs in Clinical Trials

There are now more than 23 ongoing clinical trials evaluating the safety, the pharmacokinetics, and the pharmacodynamic effects of different iBETs in several pathologies. Variants of MK-8628/OTX-015 (MK-8628-002, MK-8628-003, MK-8628-005, MK-8628-006), a potent BET inhibitor specific to BRD2/3/4 developed by Oncoethix GmbH Corp and Merck Sharp & Dohme Corp., are currently tested in oncological diseases, such as advanced solid tumors, glioblastoma multiforme, and hematological malignancies (https://ClinicalTrials.gov/NCT02259114,NCT02296476¸NCT02698189,NCT02698176). An open-label, multicenter, dose-escalation phase 1/1b study in patients with acute myelogenous leukemia or non-Hodgkin lymphoma is analyzing a novel BET inhibitor FT-1101 (specific against BRD2/3/4 and BRDT. Forma Therapeutics, Inc) (Home - ClinicalTrials.gov. (n.d.), 2019) (https://ClinicalTrials.gov/NCT02543879). Another multicentric study (phase Ib) has set out to evaluate RO6870810/TEN-010, given as mono- and combination therapy to patients with advanced multiple myeloma (https://ClinicalTrials.gov/NCT03068351.Hoffmann-LaRoche). Other trials in progressive lymphoma and multiple myeloma patients studied the sequential dose escalation of BET inhibitor CPI-0610 (specific inhibitor against BD-1 of BRD2-4/BRDT¸ Constellation Pharmaceuticals) (https://ClinicalTrials.gov/NCT02157636).

The BD2 selective inhibitor Apabetalone (RVX-208/RVX000222), developed by Resverlogix, has been evaluated in patients with diabetes mellitus type 2 and with cardiovascular diseases of high risk (https://ClinicalTrials.gov/NCT02586155). In a recent report, the bioinformatics analysis about the impact of apabetalone on the plasma proteome in patients with impaired kidney function, showed that this iBET could modulated key molecular pathways involved in immunity and inflammation, oxidative stress, endothelial dysfunction, vascular calcification, and coagulation (Wasiak et al., 2018). Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A gene inducing severe complications, including cardiomyopathy and end-stage renal disease. There is an ongoing study by Resverlogix Corp. in patients with Fabry disease and CKD testing oral apabetalone administration on key biomarkers of vascular calcification, such as RANKL and osteoprotegerin, and key markers of inflammation. such as high-sensitivity C-reactive protein (https://ClinicalTrials.gov/NCT03228940). The results of these ongoing clinical trials will help us to understand if BET inhibitors can be used in patients with cardiovascular and renal diseases (Figure 5).