Maybe we can hear some comments on the 2nd clues posted:

 2.We should not be underpowered here, more than four times the number needed in each arm to prove efficacy:

 From Congnition subgroup poster:

MoCA score change from historical data shows a standard deviation of 3.2 points predicting a necessary sample size of 54 subjects per arm to provide a 90% power to detect a mean between group difference of 2 points at p<0.05.

     BETonMace:         N =469 Patients Completed Baseline MoCA

                                       N=246 Patients with Baseline MoCA ≤ 25