Funny how science advances.  Almost like a start up company does...initiate with a business model...find it does not work as expected...then go amend it or find a new business model that works!

Re RVX, we gave up on Apo1 and HDL, which is what we started with (I hear you Cityslicker99, but this is what RVX claimed till fairly recently)...and now we are on to vascular inflammation, vascular calcification, coagulation, complement and acute phase response? Who would have thought so, 10 years back!