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Message: NFK meeting

Yes. In CKD the long-term change is for a progressive decline. But in the short-term (eg, 2 years) there can be ups as well as downs in individual subjects. Some of this might be due to measurement error. See Fig 1 in this article.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172342/?report=reader#!po=0.666667

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