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Message: BRD2 involvement in Covid19

Well, well, well...  I thought those rooting for apabetalone as a possible treatment for Covid19 were swinging for the fences but take a look at this:

"In February, the research group synthesized genes from the coronavirus and injected them into cells. They uncovered over 400 human proteins that the virus seems to rely on.

 Scientists have mapped hundreds of the proteins in human cells that the coronavirus uses to grow. Their goal is to find an antiviral drug that can prevent the virus from replicating.

The flulike symptoms observed in infected people are the result of the coronavirus attacking cells in the respiratory tract. The new map shows that the virus’s proteins travel throughout the human cell, engaging even with proteins that do not seem to have anything to do with making new viruses.

One of the viral proteins, for example, latches onto BRD2, a human protein that tends to our DNA, switching genes on and off. Experts on proteins are now using the map to figure out why the coronavirus needs these molecules.

Kevan Shokat, a chemist at U.C.S.F., is poring through 20,000 drugs approved by the Food and Drug Administration for signs that they may interact with the proteins on the map created by Dr. Krogan’s lab.

Dr. Shokat and his colleagues have found 50 promising candidates. The protein BRD2, for example, can be targeted by a drug called JQ1. Researchers originally discovered JQ1 as a potential treatment for several types of cancer."

 
https://www.nytimes.com/2020/03/17/science/coronavirus-treatment.html

Jupe

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