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Message: RVX 208 and the cytokine storm syndrome

There is a fair bit of COVID 19 research literature focusing the cytokine storm syndrome as it relates to severely ill patients.  

from a medrxiv preprint 18 Apr 2020

https://www.medrxiv.org/content/10.1101/2020.04.02.20051565v2

"The mortality of Coronavirus disease 2019 (COVID-19) appears to be driven by acute respiratory distress syndrome (ARDS) and a dysregulated immune response to SARS-CoV-2. Emerging evidence suggests that a subset of COVID-19 is characterized by the development of a cytokine storm syndrome (CSS), and interleukin (IL)-6 levels are predictors of COVID-19 severity and in-hospital mortality."

 

Going back to the January 2020 article: Pharmacological epigenetic modulators of alkaline phosphatase in chronic kidney disease (from our link library):

https://journals.lww.com/co-nephrolhypertens/fulltext/2020/01000/Pharmacologic_epigenetic_modulators_of_alkaline.3.aspx

...it appears that Apabetalone may play a part in inhibiting the deadly onset of the cytokine storm syndrome by reducing IL-6:

(near the end of the article)

"A single dose of apabetalone in CKD stage 4–5 patients rapidly resulted in reduction of numerous inflammatory cytokines, including IL-6 [2]. In the same study, proteomic profiling of more than 1300 plasma proteins predicted several immune and inflammatory pathways were activated in patients with impaired kidney function, including nuclear factor κB (NF-κB), IL-6, or bone morphogenetic protein signaling. These canonical pathways were downregulated with one dose of apabetalone, which would favourably impact progression of renal impairment and associated vascular calcification."

 

It is very frustrating that Resverlogix is sitting on "sensitive" CKD BETonMACE data at a point in time when it could help a lot of people.  It was interesting that Dr. KKZ highlighted how COVID 19 patients who were suffering with CKD (https://twitter.com/kamkalantar/status/1248299409198043137) tended to have more severe outcomes, and yet we couldn't share the NKF data with the academic world...Liberate the data Don!

 

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