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Message: BDAZ - What am I missing here??

Seems like pretty tepid results to me...am I missing something??  I think we can do much better. 

Evaluation of Ertugliflozin Efficacy and Safety Cardiovascular Outcomes Trial - VERTIS CV

https://www.acc.org/latest-in-cardiology/clinical-trials/2020/06/16/11/24/vertis#.XukB15y98ZE.twitter

 

The results of this trial indicate that ertugliflozin is noninferior to placebo for reducing CV events in patients with T2DM and established CVD. Trends were noted for beneficial effect on renal outcomes, although this was not statistically significant.

This is the fourth sodium glucose cotransporter-2 (SGLT2) drug to report on CV outcomes (after empagliflozin, canagliflozin, and dapagliflozin). There appeared to be a consistent class effect with respect to reductions in HF hospitalizations, but major adverse cardiac event reductions were statistically significant only for canagliflozin and dapagliflozin. Unlike canagliflozin, no safety signals with respect to amputations were noted. The salutary effects of ertugliflozin appear to be somewhat diminished compared with canagliflozin and dapagliflozin; it is unclear if this represents a difference in patient populations between the trials, or a true biological difference in drug efficacy (or other issues). Overall, these are important findings, even as SGLT2 inhibitors are becoming first-line agents for patients with T2DM, and also for patients with HF, with or without DM. These results add to the body of evidence supporting the use of this class in the guidelines.

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