Resverlogix 2019 Poster titled: “Apabetalone (RVX208) inhibits key drivers of vascular inflammation, calcification, and plaque vulnerability through a BET-dependent epigenetic mechanism:
https://www.resverlogix.com/upload/media_element/178/16e78195f8e4/2019-09-03-esc-vi-poster-final.pdf
Both HGMB1 and TGFB1 pathways are noted to be downregulated by ABL if I am reading this 2019 ESC poster correctly. These seem to be two key pathways the paper suggests are pro-viral.
I remain hopeful that RVX is going to stall COVID-19 replication. Keep in mind I’m not a researcher, but I am excited for the future of RVX; wish it was quicker, as we all do ;)