abo - Welcome to the RVX forum on Agoacom.com. We look forward to reading your comments in the future.

What's not to understand. It's just a brand new area of science that's been in development for a couple of decades now and does not seem to have produced any usable drugs to date. RVX's drug candidate, Apabetalone(ABL) appears to have the lead in this field but it's not quiet there yet. The human genome was mapped in around the year 2000 and now they are working on the epigenome which is the target of where ABL works.

BearDownAZ, our board leader has put together an amazing collection of information in the Link Library that you will find on the upper left side of this page. If you would like to have a better understanding of what you have invested in that's a pretty good place to start. The companies website used to have a couple of short videos that gave a simplified explanation as well but I haven't looked for a few years to see if those are still there.

In my simple understanding they have developed a "selective" BET inhibitor versus a "pan" BET inhibitor where the rest of the field seems to be at this time. The selectivity of ABL seems to be the advantage that it has over its competitors. 

In the last 20 years or so they have proven the drug is safe and that it has a positive effect on a number of target diseases but not enough of an effect to call it a drug...so far. In the most recent trial that we have seen the results of they failed to get a 30% risk reduction versus the standards of care(SOC) drugs that are used by the masses at this time, but. They did get an 18% overall risk reduction and some other exceptional insights, a 50% or so reduction in heart failure when ABL was used in conjunction with a class of drug called an SGLT2i. 

ABL seems to have a positive effect on not just one but a whole hoste of diseases. In the lead appears to be Cardio Vascular disease, Diabetes, and Cronic Kidney disease and then there is a list of about 17 or 18 additional diseases that there seems to be positive effects on.

When you add up the number of people with any one of these diseases that could possibly benefit from using this drug, if it ever gets approval to be used, the potential market has the ability to be unbelievably massive. 

It has taken the company about 20 years so far to get to this point and there is still not a salable product. The development of brand new science is very slow because the authorities want to make sure it's not going to kill you first and then provide a benefit to you second versus all of the other commonly used drugs on the market already, SOC's.

So we are here today with a drug that has recently received a Breakthrough Therapy Designation(BTD) from the FDA because of one or more of the effects that it did show it had in the recently completed BETonMACE trial. This is the first cardio vascular drug to ever receive a BTD and the potential market is very very large.

20 years is a very long time for anyone to keep an interest in anything, hence the grumpy investors(with due cause) that we see posting on the board from time to time. All of this development time and manpower comes at a cost and we the shareholders get to pay for it.

It would appear that we are finally getting to the point where a large pharmaceutical company may be interested in taking on an active role in the company through either a partnership agreement or an outright buyout. Much of the long arduous work has been done along this development path by the company on their own so far. The drug has been somewhat de-risked by the results received by the trials proformed so far but there is still another phase III trial yet to go and a New Drug Application yet to be issued.

The biggest lift in the share price, if it ever happens, should come around the time of a large pharmaceutical company taking on a major role in this company. In theory that should not be to far away now. If this comes to fruition you will be hailed as a guru as you missed the first 19 years of this saga.

Please keep in mind that I am not a scientist so the explanation is simple and may have some errors. 

Again welcome to the RVX board.

Do your own due diligence.

tada