Re: From abstract 6 days ago: BRD inhibitors are promising candidates to prevent COVID-19 mediated cardiac damage

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BKC

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Re: From abstract 6 days ago: BRD inhibitors are promising candidates to prevent COVID-19 mediated cardiac damage

in response to

Re: From abstract 6 days ago: BRD inhibitors are promising candidates to prevent COVID-19 mediated cardiac damage

golfyeti

posted on Oct 21, 2020 02:28PM

Hmmmm, I just found a catch to the article I just referred to.

It turns out that one of the tested bromodomain inhibitors is ABBV-744. ABBV-744 is a highly specific BD2 inhibitor - even more specific than Apabetalone. ABBV-744 was NOT found to be effective.

The authors ascribe the lack of effect of ABBV-744 to ABBV-744 being an androgen receptor inhibitor - that explanation is probably a misunderstandig by the authors. Thus, a cursory search of ABBV-744 does not suggest that ABBV-744 inhibits the androgen receptor, although ABBV-744 has been reported to have an effect on Androgen Receptor driven prostate cancer.

While I remain optimistic that Apabetalone has a positive effect on atherosclerosis/heart failure, I cannot say that the article I just referenced supports that Apabetalone prevents cardiac dysfunction in COVID19.