Plus - i think posted by someone already, but this re delays on  BETonMACE type trials

https://www.clinicaltrialsarena.com/comment/disrupted-clinical-trials-slow-recruitment/

Delays seem to be affecting many biotechs now

Don't think we can put all the blame on Don for this. Not sure, but does seem likely there could be factors beyond his control.

And it does seem  from the other article (not the one above) that maybe even some of those with breakthrough designations have been affected.