Here's what I've got on NAFLD and NASH

NAFLD (Non-alcoholic Fatty Liver Disease)

  This one is from you! Ha!

https://agoracom.com/ir/Resverlogix/forums/discussion/topics/761346-nafld/messages/2317559#message

NASH (Non-alcoholic Steatohepatitis)

https://www.barrons.com/articles/biotechs-liver-disease-nash-sector-tumbles-51621955113?siteid=yhoof2

https://www.investors.com/news/technology/nash-liver-disease-treatment-biotech-companies-billions-sales/

https://www.nature.com/articles/s41598-018-35653-4

 https://www.cnbc.com/2018/12/21/the-35-billion-race-for-a-cure-for-a-liver-disease-that-affects-millions.html

Nlrp3 and the inflamasome activation (Parkinsons, Alzheimers, gout)

"NLRP3 has also been linked via preclinical data with nearly two dozen other conditions — including atherosclerosis, Alzheimer disease, gout, Parkinson disease, rheumatoid arthritis and non-alcoholic steatohepatitis (NASH).  

“All the big pharma companies want to block this target. It ticks all the boxes,” says O’Neill.""

https://www.nature.com/articles/d41573-019-00086-9

Apabetalone down-regulates NLRP3. (need link proper poster) 

https://www.fiercebiotech.com/biotech/acquisitive-allergan-buys-micro-cap-nash-biotech-tobira-months-after-trial-miss