"Could you please give us a better understanding of what they are talking about in the Cell report regarding the lungs that didn't get any worse after being subject to APB?"

"Thank you imtesty that is the exact area I was referring to."

None of that section of the Mills Cell 2021 paper includes any administration of apabetalone to an intact animal; only 2D cell culture and organoid models. These are far from sufficient in replicating the complex physiology of an intact animal and also do not replicate the complex pharmacodynamics of drug distribution after oral delivery. Also, that section of the Mills Cell 2021 paper does not refer to lungs after apabetalone treatment. The only mouse model work in that paper that uses BETi uses INCB054329, not apabetalone.

BDAZ