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Message: FDA approves "empagliflozin" for reducing risk of cardiovascular death, hospitalization among adult HFpEF patients

I was going to address this pre-emptively but then didn't want to complicate things unncessarily.

 

Since you mentioned, yes most people with diabetes die from CVD and that's why a lot of treatments try to reduce morbidity / mortality associated CVD not just lowering blood sugar level in patients with diabetes.

 

RVX trial did just that, i.e. trying to reduce composite endpoints for CVD in patients with diabetes.

 

I didn't read the EMPEROR trial, but I bet some patients had diabetes on top of heart failure.

 

Yes, these heart failure and didabetes can co-exist in patients but main inclusion criteria for BOM trial is diabetes plus CVD and those for EMPEROR trial is heart failure plus/minus other comorbidities.

 

Plus, BOM1 trial primary endpoint didn't meet statistical significance (DM should also be clear abt this on his slide).

 

 

 

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