• Published: 20 July 2022

APOA1 mRNA and protein in kidney renal clear cell carcinoma correlate with the disease outcome

• Wei Zeng, 
• Guoguang Xiong, 
• …
• Xiulan Peng

"...APOA1 belongs to the family of apolipoproteins A1/A4/E and plays an essential role in lipid metabolism39. Cristina et al.11 found that the overexpression of APOA1 can reduce the malignant features of colorectal cancer by regulating cholesterol export and downregulating COX-2 expression. Therefore, apabetalone, a synthetic stimulator of APOA1, is recognized as an inhibitor against colorectal cancer. The authors concluded that APOA1 could be a new therapeutic target for the treatment of colorectal cancer by modulating lipid metabolism. APOA1 has also been implicated in the progression of renal cell cancer through the regulation of lipid metabolism40, and APOA1 inhibition may be effective for treating renal cell cancer. More studies of APOA1 stimulators, such as apabetalone, to treat renal cell cancer are warranted...."