https://finance.yahoo.com/news/resverlogix-publishes-data-highlighting-apabetalone-111200212.html

ALGARY, Alberta, Aug. 22, 2022 (GLOBE NEWSWIRE) -- Resverlogix Corp. ("Resverlogix") (TSX:RVX) today announced the publication of an article entitled “Reduction in the Risk of Major Adverse Cardiovascular Events with the BET Protein Inhibitor Apabetalone in Patients with Recent Acute Coronary Syndrome, Type 2 Diabetes, and Moderate to High Likelihood of Non-Alcoholic Fatty Liver Disease” in the American Journal of Preventive Cardiology. The article presents a post-hoc analysis of BETonMACE data, which demonstrates apabetalone treatment improves cardiac outcomes and liver fibrosis scores in patients with moderate-to-high likelihood of advanced liver fibrosis.

The article is published online HERE.

“In this patient group, apabetalone treatment was associated not only with fewer negative cardiovascular outcomes, but also relative improvements in liver fibrosis score,” said Dr. Peter P. Toth, Director of Preventive Cardiology at CGH Medical Center in Sterling, IL, and the corresponding author of the article. “These promising findings make the case for a larger study of non-alcoholic fatty liver disease patients to better understand the scope of apabetalone’s benefit.”

Publication Highlights Include:

• Angulo fibrosis score (FS) has a validated association with non-alcoholic fatty liver disease prevalence

• BETonMACE participants with an elevated FS had higher incidences of major adverse cardiac events (MACE) and hospitalizations due to heart failure (HHF)

• Apabetalone treatment reduced the hazard of HHF (HR=0.53, p=0.01), as well as a composite MACE and HHF (HR=0.76, p=0.03) in BETonMACE participants with elevated FS

• In comparison to the placebo group, patients who received apabetalone treatment saw significantly smaller increases in their liver fibrosis scores