...We Welcome You To The Resverlogix HUB withIn The AGORACOM COMMUNITY!

Reply New Message

Prev Message Back To Forum Threaded View Next Message

KOO-KOO2

Rank: Treasurer [?]

Points: 10765 [?]

Votes: 39 Score: 2.3 [?]

Your Vote:

Please Log In to Vote

Did you know? You can earn activity points by filling your profile with information about yourself (what city you live in, your favorite team, blogs etc.)

Re: At least apabetalone shows up in a table here...

in response to

At least apabetalone shows up in a table here...

imtesty

posted on Sep 05, 2022 09:04AM

COVID-19 Treatment: Investigational Drugs and Other Therapies

Updated: Aug 25, 2022

Author: Scott J Bergman, PharmD, FCCP, FIDSA, BCPS, BCIDP;

Table 2. Investigational Drugs for ARDS/Cytokine Release Associated With COVID-19 (Open Table in a new window)

Drug	Description

Apabetalone (Resverlogix Corp) [183]

"Bromodomain and extra-terminal domain (BET) protein function is required for inflammation. BET inhibitors reversibly bind the bromodomains of BET proteins and prevent the protein-protein interaction between BET proteins and acetylated histones and transcription factors. Apabetalone, a BET inhibitor, reduces the expression of both ACE2 and DPP4 at the surface of human lung epithelial cells. As of January 2022, a phase 2/3 study has commenced in hospitalized patients compared with standard of care."