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“The oncoming burden of long COVID faced by patients, health-care providers, governments and economies is so large as to be unfathomable,” says one of the most comprehensive reviews yet of the possible mechanisms and treatments for the condition. The study estimates that some 400 million people globally are in need of support for long COVID, “but we don't really know even the full list of which drugs we’d put into a clinical trial tomorrow, given the chance”, says immunologist Danny Altmann, who led the review.