Re: Zenith Epigenetics Announces Initiation of a Phase 2b Triple Negative Breast Cancer (TNBC) Clinical Trial
posted on
May 14, 2022 01:15PM
Zenith's BET Inhibitor ZEN-3694 is Currently Being Evaluated in Multiple Oncology Clinical Trials
Apabetalone finished the ASSURE trial in 2013 at the same time Zenith was started. Yes, it failed but the 2b cancer trials can fail also. It has taken Zenith 9 years to get here. I think it is safe to say that Zenith had a head start in 2013 compared to where Apabetalone was in 2004, nine years before ASSURE. It seems that the cancer trials are going just as slow or slower than the Apabetalone trials to this point even though DM said back in 2013 that they would be much faster. Yes, Apabetalone has ground to a halt in recent years but we can't compare that to the cancer trials as they haven't gone through this stage yet. I don't think the cancer trials have moved ahead any faster than Apabetalone below. Unfortunately, Apabetalone has ground to a halt since but we can only hope that doesn't also happen to the cancer trials when they reach this stage.
1a - 2008
1b/2a - announced Aug/08 and results announced Aug./09
ASSERT & ASSURE1 (pre ASSURE trials for dosing, etc.) - announced in Oct./09 and completed in Feb. and Nov./10.
ASSURE 2b (IVUS) - announced June/11 and done two years later in 2013.
SUSTAIN - announced in Sept./11 and completed Aug./12.