Rusults of a recently published, independent, study link the use of the arsenic based coccidiostat, Roxarsone, to cancer in humans.

Pharmacentical manufacturer Alpharma, maker of roxarsone, had "no comment". (You may remember Alpharma as characterizing opponents of the use of antibiotic growth promoters as "professional handwringers".)

Alpharma, along with several Arkansas broiler processors, including Tyson and Cargill, were the defendants in a major law suit brought in 2004 by residents of Prairie Grove, AK. The residents of Prairie Grove had an unusually high incidence of cancer, and other illnesses, and blamed the presence of arsenic from poultry waste that had leeched into the water supply. They blamed this high level of arsenic on Alpharma's Roxarsone.

The EPA, and the U S Geological Survey have both confirmed the unusually hign presence of arsenic in the ground where chicken manure has been spread, as well as higher levels of arsenic in nearby groundwater. Though government agencies confirmed high levels of arsenic in the environment, as a result of Roxarsone in chicken manure, links to resulting illnesses, including cancer have been unsubstantiated, until now.

This most recent study contributes to the growing evidence that US poultry producers need to be moving away from the use of sub-therapeutic antibiotics and coccidiostats, and replacing them with all-natural products (like AGRASTIM) that perform equally as well, or better, than currently used products, without long-term detrimental effects to human health.

-zties

Chicken feed additive may pose danger

Thursday, February 07, 2008
By Don Hopey, Pittsburgh Post-Gazette

A chicken feed additive containing arsenic and used to produce pinker, healthier, bigger-breasted birds could cause human disease, according to a study headed by a Duquesne University researcher.

The study is the first to link a human health risk to the feed additive that has been widely used since the 1960s by commercial chicken producers to control intestinal parasites, reduce stress, stimulate growth and improve the color of chicken meat.

Dr. Partha Basu, the study's lead author and associate professor in Duquesne's Department of Chemistry and Biochemistry, said laboratory analysis reveals that the antibiotic arsenic compound roxarsone, which promotes the growth of blood vessels in chickens to produce pinker meat, does the same in human cell lines -- a critical first step in many human diseases, including cancer.

"This is a significant finding as it relates to potential human health effects from roxarsone," said Dr. Basu, who worked on the study with scientists from Thermo Fisher Scientific laboratories and the University of Pittsburgh's Department of Environmental and Occupational Health.

"We wanted to test if roxarsone, which increases pigmentation by forming more blood vessels in chickens, does the same in humans and the answer is yes," Dr. Basu said. "It's a process called angiogenesis, a common growth process, but also one that occurs in many diseases and cancers."
Results of the study have been published in Environmental Health Perspectives, an online journal of the National Institute of Environmental Health Sciences, which supported the study.

Although the effect of roxarsone on those who eat chicken is still undetermined, Dr. Basu said, chicken-farm workers are likely at risk because they could inhale dust containing arsenic from feed and waste. In addition, those who work with or use commercial fertilizers containing waste from chickens that were fed the arsenic additive could also be exposed by breathing the dust.

The National Chicken Council, a Washington, D.C.-based trade organization for the poultry industry, wasn't aware of the study but maintained that roxarsone is safe and is approved by the Food and Drug Administration.

"The study is based on lab tests. There's nothing epidemiological about it," said Richard Lobb, a spokesman for the council, who emphasized that the study is not based on reports of actual illnesses. "It will need to be repeated and confirmed by other researchers."

Alpharma Inc., the global specialty pharmaceutical company that makes roxarsone, declined comment.

U.S. chicken producers use a total of 2.2 million pounds of roxarsone each year. About 70 percent of the 9 billion fryer chickens grown annually nationwide eat feed containing the additive, which also is used in turkey and pig feed.

More than 95 percent of the roxarsone fed to chickens is excreted unchanged in chicken waste, which is regularly applied as fertilizer on surrounding farm fields or used in commercial fertilizers. The arsenic from those applications could leach into surface and ground water supplies.

The new study is a follow-up to one released by Dr. Basu and other Duquesne University researchers last March that found the organic arsenic feed additive is chemically transformed into inorganic arsenic, a known carcinogen, much more quickly than previously thought.

Arsenic occurs naturally in the environment, but industrial discharges by coal-burning power plants, industries and some mining operations are closely regulated. Its use in pesticides and as a wood preservative has been banned due to health concerns and the difficulty in removing it from the environment.

Chronic exposure to inorganic arsenic is known to cause cancer and has been linked to heart disease, diabetes and declines in brain functions.

Other studies have found the arsenic feed additive in dust inside rural homes near chicken farms and in ground water.

The study doesn't focus on the risks of eating chickens that were fed roxarsone, but Dr. Basu said there are reasons to be cautious.

"A 2006 University of Minnesota study bought fast food chicken in California and Minnesota and found high levels of arsenic," Dr. Basu said. "It's hard to say which chicken product might contain arsenic, but if it does, one should be careful. But not all of them do."

The European Union declared the use of roxarsone undesirable in 1999, and its members no longer use it.

Scott Sechler, Pennsylvania's biggest chicken producer, sells a million birds a week and doesn't use roxarsone or any other arsenic additive. He markets his birds under the Farmers Pride and Bell & Evans labels, carried in Western Pennsylvania by Whole Foods and Giant Eagle.

Tyson Foods, the nation's second biggest chicken producer stopped using arsenic additives in July 2004, and Perdue Farms, the nation's fifth biggest, stopped in April 2007.

"We just found we didn't need to use it any more," said Julie DeYoung, a Perdue spokeswoman. "We're relying on improved management programs to keep our birds healthy."

Don Hopey can be reached at dhopey@post-gazette.com or 412-263-1983.
First published on February 7, 2008 at 12:00 am