In March 2007, PUBPAT filed formal requests with the United States Patent and Trademark Office challenging four key HIV/AIDS drug patents held by Gilead Sciences, Inc. (NASDAQ: GILD). As part of its requests, PUBPAT submitted prior art that the Patent Office did not review before granting the patents to the Foster City, California, biopharmaceutical giant. PUBPAT also explained how the submitted prior art invalidates the patents and asked that the Patent Office undertake a review and revoke them. In July 2007, the Patent Office granted each of PUBPAT's requests and ordered reexamination of all four patents.

In January 2007, PUBPAT filed a formal request with the United States Patent and Trademark Office to review a patent held by Patriot Scientific (OB: PTSC) that the company, which boasts of "primarily focusing on deriving revenue from licensing patents", is widely asserting against producers of computer microprocessors. In its filing, PUBPAT submitted prior art that the Patent Office was not aware of when reviewing the application that led to the issuance of the patent, described in detail how the prior art invalidates the patent and asked that the patent be revoked. In April 2007, the Patent Office granted PUBPAT's request for reexamination of the patent.

In January 2007, PUBPAT filed a formal request with the United States Patent and Trademark Office to review a patent held by Opsware Inc. (NASDAQ: OSPW) that relates to remote computer management, but was preempted by the work of open source projects. In its filing, PUBPAT submitted prior art that the Patent Office was not aware of when reviewing the application that led to the issuance of the patent (U.S. Patent No. 7,124,289), described in detail how the prior art invalidates the patent and asked that the patent be revoked. In April 2007, the Patent Office granted PUBPAT's request for reexamination of the patent.

In November 2006, PUBPAT filed formal requests with the United States Patent and Trademark Office to review two patents held by epicRealm Licensing Inc. that the patent licensing company - which offers no products or services - is widely asserting against providers of dynamic websites, i.e. websites that can produce custom responses to individual visitors or users. In its filings, PUBPAT submitted prior art that the Patent Office was not aware of when reviewing the applications that led to the two patents, described in detail how the prior art invalidates the patents and asked that the patents be revoked. In January, 2007, the Patent Office granted PUBPAT's requests.