SanFran,
Look up the Evacetrapib CETP-inhibitor ACCELERATE trial. The CETP inhibitors also raise HDL, as most of us know; albeit a completely different mechanism. ACCELERATE had 5-point MACE as a readout. Started in 2012 with over 10,000 patients on drug for at least 1.5 years. Called off due to futility in October 2015.
BearDownAZ